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Leucovorin Prescriptions for Autism Spectrum Soar After White House Promotion, But FDA Cites 'Insufficient Evidence'
Leucovorin Prescription Surge and White House Announcement Controversy
Following a White House press conference in September 2025, a graph revealed a 71% surge in prescriptions for Leucovorin, a drug for children with autism spectrum disorder. At the time, U.S. Secretary of Health and Human Services Robert F. Kennedy Jr. referred to Leucovorin as a 'breakthrough therapy' that could help autistic children, and FDA Director Dr. Marty Makary claimed that hundreds of thousands of children would benefit.
FDA Denies Approval for Autism Spectrum Treatment
However, according to an article dated March 10, 2026, the FDA has only approved Leucovorin for the rare genetic disorder 'cerebral folate deficiency' and has not approved its widespread use for autism spectrum disorder. A senior FDA official stated that there is currently insufficient data to prove the efficacy of Leucovorin for autism spectrum disorder. Consequently, parents of children with autism spectrum disorder have expressed significant disappointment.
Expert Recommendation: Consult a Specialist and Undergo Genetic Testing
Pediatric neurologist Dr. Audrey Brumback concurred with the FDA's decision, emphasizing the lack of evidence to support the widespread use of Leucovorin for autism spectrum disorder. She advised that high doses of Vitamin B (a form of Leucovorin) can be risky, and therefore, anyone considering using the drug must consult a trusted medical professional who can monitor side effects and potential benefits. She also added that effective interventions exist for other symptoms associated with autism spectrum disorder, such as anxiety, insomnia, constipation, and ADHD symptoms, and recommended working with a specialist to undergo genetic testing.
*Source: YouTube: CNN (2026-03-10)*
